Education and support to help you manage your health condition

To learn more about your treatment and your condition, select any of the topics below or scroll down.

Watch a video about the infusion process

A health care professional will give you RENFLEXIS as an intravenous (IV) infusion. This means a needle will be placed in a vein—most likely in your arm.

Watch this video to learn about the infusion process and get helpful tips on how to prepare for your treatment.

Your Introduction To Infusions
Preparing For Your Infusion
On Your Infusion Day
The Infusion Center
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Your Introduction To Infusions
Preparing For Your Infusion
On Your Infusion Day
The Infusion Center




Your introduction to Infusions


Brought to you by:



So, what is an infusion?


It’s a way of delivering medicine…

…Directly into the bloodstream


Through an IV (Intravenous Infusion)


Usually given by an infusion nurse


Your dose will be decided by your doctor


So it’s customized just for YOU


Different medicines take different amounts of time to infuse.


Your doctor will let you know…

... how long your infusion process will be.


And will determine how many doses of medicine you will need.


Coming up next: Preparing For Your Infusion



Preparing For Your Infusion


The day before your appointment


There are several things to consider before your appointment…


Confirm your appointment with the infusion center.


Update your doctor on any changes to your medical history…


…or if you’re not feeling well.


Consider bringing family or a close friend with you to the infusion center.


Follow your doctor’s guidelines


DRINK plenty of water the night before your infusion.


When you’re hydrated it may be easier

for the nurse to start the infusion.


And one more thing…


Get a good night’s rest


Coming up next: On Your Infusion Day



On Your Infusion Day


Getting ready is simple


If your doctor says it’s okay, be sure to have a healthy breakfast


Wear comfortable, loose-fitting clothes


Pack up and plan for “me time”


Here are a few ideas


Bring a list of other medicines you take and your insurance card


Now you’re good to go


Coming up next: The Infusion Center



Welcome to the Infusion Center


Every infusion center is different


You may even have an infusion at home


but the infusion process in similar


An infusion nurse will check the following:


Blood Pressure








Your weight may be checked.


Your doctor will determine your dose.


An infusion nurse prepares your medicine and starts the infusion.


And will check in on you during your infusion.


Make good use of your “me time”


When your infusion is over, your nurse will check on you


and send you on your way once you have been cleared to go.


Don’t forget to confirm your next appointment on your way out.


And you’re done until next time.


Brought to you by:



Copyright © 2017 Merck Sharp & Dohme Corp.,

a subsidiary of Merck & Co., Inc.,

All rights reserved. BIOS-1197876-0001 09/17

Download information about RENFLEXIS

Informative resources that you can download are available here. These include an educational brochure on how RENFLEXIS can help treat your health condition, a guide to making the transition to RENFLEXIS from Remicade® (infliximab), and questions you may want to ask your doctor.

Connect with these helpful organizations

If you’d like to learn more about your condition, connect with others who may be facing the same challenges as you, or join a local support group, visit the websites of the patient organizations below.

Learn more about The Merck Access Program

Important Safety Information

Only your doctor can recommend a course of treatment after checking your health condition. RENFLEXIS can cause serious side effects such as lowering your ability to fight infections. Some patients, especially those 65 years and older, have had serious infections caused by viruses, fungi, or bacteria that have spread throughout the body, including tuberculosis (TB) and histoplasmosis. Some of these infections have been fatal. Your doctor should monitor you closely for signs and symptoms of TB during treatment with RENFLEXIS.

Unusual cancers have been reported in children and teenage patients taking TNF-blocker medicines. Hepatosplenic T-cell lymphoma, a rare form of fatal lymphoma, has occurred mostly in teenage or young adult males with Crohn’s disease or ulcerative colitis who were taking infliximab products and azathioprine or 6-mercaptopurine. For children and adults taking TNF blockers, including RENFLEXIS, the chances of getting lymphoma or other cancers may increase.

You should discuss any concerns about your health and medical care with your doctor.

What should I tell my doctor before I take RENFLEXIS?

You should let your doctor know if you have or ever had any of the following:
  • Tuberculosis (TB) or have been near someone who has TB. Your doctor will check you for TB with a skin test. If you have latent (inactive) TB, you will begin TB treatment before you start RENFLEXIS. If your doctor feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with, and during treatment with, RENFLEXIS. Even if your TB test is negative, your doctor should carefully monitor you for TB infections while you are taking RENFLEXIS. Patients who had a negative TB skin test before receiving infliximab products have developed active TB.
  • Lived in a region where certain fungal infections like histoplasmosis, coccidioidomycosis, cryptococcosis, or blastomycosis are common. These infections may develop or become more severe if you take RENFLEXIS. If you do not know if you have lived in an area where histoplasmosis, coccidioidomycosis, cryptococcosis, or blastomycosis is common, ask your doctor.
  • Infections that keep coming back, diabetes, or an immune system problem.
  • Any type of cancer or a risk factor for developing cancer, for example, chronic obstructive pulmonary disease (COPD) or had phototherapy for psoriasis.
  • Heart failure or any heart condition. Many people with heart failure should not take RENFLEXIS.
  • Hepatitis B virus (HBV) infection or think you may be a carrier of HBV. Your doctor will test you for HBV.
  • Nervous system disorders (like multiple sclerosis or Guillain-Barré syndrome).
Also tell your doctor if you:
  • Use the medicines Kineret® (anakinra), Orencia® (abatacept), or Actemra® (tocilizumab) or other medicines called biologics used to treat the same problems as RENFLEXIS.
  • Are pregnant, plan to become pregnant, are breast-feeding, or have a baby and were using RENFLEXIS during your pregnancy. Tell your baby's doctor about your RENFLEXIS use. If your baby receives a live vaccine within 6 months after birth, your baby may develop infections with serious complications that can lead to death.
  • Recently received or are scheduled to receive a vaccine. Adults and children taking RENFLEXIS should not receive live vaccines or treatment with a weakened bacteria (such as Bacille Calmette-Guérin [BCG] for bladder cancer) while taking RENFLEXIS.

What should I watch for and talk to my doctor about before or while taking RENFLEXIS?

The following serious (sometimes fatal) side effects have been reported in people taking RENFLEXIS.

You should tell your doctor right away if you have any of the signs listed below:

  • Infections (like TB, blood infections, pneumonia)—fever, tiredness, cough, flu, or warm, red, or painful skin or any open sores. RENFLEXIS can make you more likely to get an infection or make any infection that you have worse.
  • Lymphoma, or any other cancers in adults and children.
  • Skin Cancer—any changes in or growths on your skin.
  • Cervical Cancer—your doctor may recommend that you be regularly screened. Some women with rheumatoid arthritis, particularly those over 60, have developed cervical cancer.
  • Heart Failure—new or worsening symptoms, such as shortness of breath, swelling of your ankles or feet, or sudden weight gain.
  • Reactivation of HBV—feeling unwell, poor appetite, tiredness, fever, skin rash, and/or joint pain.
  • Other heart problems within 24 hours of infusion, including heart attack, low blood flow to the heart, or abnormal heart rhythm—chest discomfort or pain, arm pain, stomach pain, shortness of breath, anxiety, lightheadedness, dizziness, fainting, sweating, nausea, vomiting, fluttering or pounding in your chest, and/or a fast or a slow heartbeat.
  • Liver Injury—jaundice (yellow skin and eyes), dark brown urine, right-sided abdominal pain, fever, or severe tiredness.
  • Blood Problems—in some patients taking infliximab products, the body may not make enough of the blood cells that help fight infections or help stop bleeding. Tell your doctor if you have a fever that does not go away, bruising, bleeding, or severe paleness.
  • Nervous System Disorders—numbness, weakness, tingling, changes in your vision, or seizures.
  • Stroke within 24 hours of infusion—numbness or weakness of the face, arm, or leg, especially on one side of the body; sudden confusion, trouble speaking or understanding; sudden trouble seeing in one or both eyes; sudden trouble walking; dizziness; loss of balance or coordination; or a sudden, severe headache.
  • Allergic Reactions (some severe) during or after the infusion—hives, difficulty breathing, chest pain, high or low blood pressure, swelling of face and hands, and fever or chills.
  • Delayed Allergic Reactions (3 to 12 days after infusion)—fever, rash, headache, sore throat, muscle or joint pain, swelling of the face and hands, or difficulty swallowing.
  • Lupus-like Syndrome—chest discomfort or pain that does not go away, shortness of breath, joint pain, rash on the cheeks or arms that gets worse in the sun.
  • Psoriasis—new or worsening psoriasis such as red scaly patches or raised bumps on the skin that are filled with pus.

The more common side effects with infliximab products are respiratory infections (that may include sinus infections and sore throat), headache, rash, coughing, and stomach pain.

What conditions is RENFLEXIS used to treat?
RENFLEXIS is a prescription medication used to treat: Crohn's Disease
  • Can reduce signs and symptoms and induce and maintain remission in adult patients with moderately to severely active Crohn’s disease who haven’t responded well to other therapies
Pediatric Crohn's Disease
  • Can reduce signs and symptoms and induce and maintain remission in children (ages 6–17) with moderately to severely active Crohn’s disease who haven’t responded well to other therapies
Ulcerative Colitis
  • Can reduce signs and symptoms, induce and maintain remission, promote intestinal healing, and reduce or stop the need for steroids in adult patients with moderately to severely active ulcerative colitis who haven’t responded well to other therapies
Rheumatoid Arthritis
  • Can reduce signs and symptoms, help stop further joint damage, and improve physical function in patients with moderately to severely active rheumatoid arthritis, in combination with methotrexate
Psoriatic Arthritis
  • Can reduce signs and symptoms of active arthritis, help stop further joint damage, and improve physical function in patients with psoriatic arthritis
Ankylosing Spondylitis
  • Can reduce signs and symptoms in patients with active ankylosing spondylitis
Plaque Psoriasis
  • Approved for the treatment of adult patients with chronic (doesn’t go away) severe (extensive and/or disabling) plaque psoriasis under the care of a physician who will determine if RENFLEXIS is appropriate considering other available therapies

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

Please read the accompanying Medication Guide for RENFLEXIS, including the information about serious infections and cancers, and discuss it with your doctor. The physician Prescribing Information also is available.

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Copyright © 2019 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. All rights reserved. US-SBT-00319 05/19

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Please read the accompanying Medication Guide for RENFLEXIS, including the information about serious infections and cancers, and discuss it with your doctor. The physician Prescribing Information also is available.